Tumor molecular subtype

Articles

• PDGFRA-mutated GIST
  28 November 2011

  PDGFRA-associated GIST

• ALK-associated tumors
  13 December 2011

  Types
  ALK+ anaplastic large cell lymphoma (ALK+ ALCL) ALK- anaplastic large cell lymphoma (ALK- ALCL)
  ALK-associated pulmonary adenocarcinoma
  ALK-associated inflammatory myofibroblastic tumor
  ALK-associated epithelioid inflammatory myofibroblastic sarcoma (RANBP2-ALK)
  Images
  https://twitter.com/bestpathologist/status/709155294815727616
  See also
  ALK

• SDHA-deficient renal cell carcinoma
  5 March 2015

  SDHA-associated renal cell carcinoma
  Succinate dehydrogenase (SDH)-deficient renal cell carcinoma (RCC) is an emerging provisional entity included in the 2013 International Society of Urological Pathology Vancouver Classification.
  Most genomic alterations in patients with SDH-deficient RCCs involve the SDHB subunit, and the associated renal tumors have loss of immunohistochemical SDHB expression and distinctive morphologic features.
  Renal tumors less commonly possess genomic alterations (...)

• BRCA1-associated ovarian carcinoma
  19 May 2008

  BRCA1 Ovarian Cancer Phenotype
  The combination of modified Nottingham grade 3 serous or undifferentiated histology, prominent intraepithelial lymphocytes, marked nuclear atypia with giant/bizarre nuclei, and high mitotic index should help to identify women for BRCA1 mutational analysis in the appropriate clinical setting. (#22790858#)
  Ovarian tumors lacking this specific phenotype are unlikely to be associated with BRCA1 and should not undergo mutational analysis in the absence of other (...)