Disease

Articles

• ulcerative colitis
  2 March 2004

  Definition: Ulcerative colitis (UC) is generally considered an inflammatory disorder that always involves the rectum and may also involve more proximal portions of the colon, but always in a diffuse and continuous (non-segmental) fashion.
  Earlier biopsy studies have shown that both rectal sparing and patchy disease may occur during the natural history of UC and may, in fact, be accentuated by oral or enema therapy. (#20410806#)
  Images
  ulcerative colitis : ruptured crypt granuloma : (...)

• Griscelli disease
  17 September 2003

  Griscelli syndrome

• pyoderma gangrenosum
  11 February 2004

  Definition: Pyoderma gangrenosum (PG) is an uncommon, chronic ulcerative condition of the skin that was first described in 1930. It can occur in any age group, but only 4% of the patients are infants or children. An underlying systemic disease is present in approximately 50% of the patients with PG.
  The most common associations include inflammatory bowel disease, arthritis, lymphoproliferative disorders and chronic recurrent multifocal osteomyelitis (CRMO).
  Pyoderma gangrenosum (PG) is a (...)

• 22q11.2 deletion syndrome
  3 October 2003

  DiGeorge syndrome, DiGeorge’s syndrome, 22q11 deletion syndrome, CATCH22, DiGeorge disease

• sarcoidosis
  22 September 2003

  Sarcoidosis is a granulomatous disorder of unknown etiology, associated with an accumulation of CD4+ T cells and a TH1 immune response. WP
  Images
  hepatic sarcoidosis https://twitter.com/Hopkins_GI_Path/status/675402892036173826
  cutaneous sarcoidosis https://twitter.com/RyanHickMD/status/731249607909351424
  Sarcoidosis: all types of giant cells and endogenous inclusions occur, none are specific https://twitter.com/smlungpathguy/status/879435684540538884
  Links
  Sarcoidosis in (...)

• Cystic fibrosis
  27 June 2003

  mucoviscidosis

• epidermolysis bullosa simplex
  19 March 2004

  Types
  KRT14-associated epidermolysis bullosa simplex Koebner type epidermolysis bullosa simplex (MIM.131900) Dowling-Meara type epidermolysis bullosa simplex (MIM.131760) recessive epidermolysis bullosa simplex Weber-Cockayne type epidermolysis bullosa simplex (MIM.131800)
  References
  Schroder R, Kunz WS, Rouan F, Pfendner E, Tolksdorf K, Kappes-Horn K, Altenschmidt-Mehring M, Knoblich R, van der Ven PF, Reimann J, Furst DO, Blumcke I, Vielhaber S, Zillikens D, Eming S, Klockgether T, (...)

• relapsing polychondritis
  16 June 2004

  CLINICAL: painful erythema and edema involving both ears and nose, eventually leading to flabby ears and saddle nose
  HISTOPATHOLOGY: mixed inflammatory infiltrate (lymphocytes, plasma cells, and neutrophils) involving the deep dermis and cartilage. Cartilage cell vacuolisation and pyknosis leading to total destruction and replacement by fibrous tissue
  DIFFERENTIAL: chondrodermatitis nodularis chronica (...)

• transient acantholytic dermatosis
  16 June 2004

  Grover disease (GD), benign papular acantholytic dermatosis, transient acantholytic dermatosis, persistent acantholytic dermatosis WKP
  Definition: Grover’s disease (GD) is a polymorphic, pruritic, papulovesicular dermatosis characterized histologically by acantholysis with or without dyskeratosis.
  Once confirmed, most cases of Grover’s disease last six to twelve months, which is why it was originally called "transient". Unfortunately it may last much longer. Nevertheless, it is not to (...)

• xeroderma pigmentosum
  6 March 2004

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