DNA glycosylase MYH, homolog of E. coli MutY; mutY homolog (E. coli)
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Inactivated in tumors
Articles
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MUTYH
20 November 2003 -
STK11
29 October 2003XEEK1, LKB1
Definition: STK11 (LKB1) is a serine-threonine protein kinase mutated in patients with an autosomal dominantly inherited cancer syndrome predisposing to multiple benign and malignant tumours, termed Peutz-Jeghers syndrome.
LKB1 has been implicated as a regulator of multiple biological processes and signaling pathways, including the control of cell-cycle arrest, p53-mediated apoptosis, Wnt signaling, transforming growth factor (TGF)-beta signaling, ras-induced cell (...) -
BRCA1
29 September 2003Wikipedia
Definition: BRCA1 is a tumor suppressor that functions in controlling cell growth and maintaining genomic stability. The breast and ovarian cancer susceptibility gene BRCA1 encodes a zinc-finger protein of unknown function.
BRCA1 is a tumour suppressor that has important roles in the protection against genomic instability.
Cells lacking BRCA1 are hypersensitive to many DNA-damaging agents such as ultraviolet light and ionizing radiation, and show defects in both S- and (...) -
TGFBR2
3 September 2007transforming growth factor beta (TGFB) Type II receptor (TGFBR2)
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DLEC1
3 September 2007Deleted in Lung and Esophageal Cancer 1
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AKT1
24 November 2004Proteine kinase B, PKB, PKB-alpha, Proteine kinase B-alpha
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PRDM2
19 March 2006RIZ1
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MLH1
29 September 2003mismatch repair gene
MLH is homologous to the E. coli MutL gene and is involved in DNA mismatch repair. Mutations in the MLH1 gene result in hereditary nonpolyposis colorectal cancer-2 (HNPCC2) (MIM.609310).
Pathology
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant cancer predisposition syndrome caused by inherited germ line mutations in DNA mismatch repair genes, predominantly MSH2 and MLH1.
MLH1 loss of expression (...) -
SMARCB1
24 November 2003INI1, SNF5, INI1/SNF5
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FLCN
27 November 2004folliculin, FLCL
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