Inactivated in tumors

Articles

• BRCA1
  29 September 2003

  Wikipedia
  Definition: BRCA1 is a tumor suppressor that functions in controlling cell growth and maintaining genomic stability. The breast and ovarian cancer susceptibility gene BRCA1 encodes a zinc-finger protein of unknown function.
  BRCA1 is a tumour suppressor that has important roles in the protection against genomic instability.
  Cells lacking BRCA1 are hypersensitive to many DNA-damaging agents such as ultraviolet light and ionizing radiation, and show defects in both S- and (...)

• VHL
  23 September 2003

  The protein encoded by the VHL gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity.
  This complex is involved in the ubiquitination and degradation of a hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen.
  RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript (...)

• PTEN
  25 July 2003

  Phosphatase and tensin homolog, MMAC1

• PRDM2
  19 March 2006

  RIZ1

• SMARCB1
  24 November 2003

  INI1, SNF5, INI1/SNF5

• DLEC1
  3 September 2007

  Deleted in Lung and Esophageal Cancer 1

• TGFBR2
  3 September 2007

  transforming growth factor beta (TGFB) Type II receptor (TGFBR2)

• STK11
  29 October 2003

  XEEK1, LKB1
  Definition: STK11 (LKB1) is a serine-threonine protein kinase mutated in patients with an autosomal dominantly inherited cancer syndrome predisposing to multiple benign and malignant tumours, termed Peutz-Jeghers syndrome.
  LKB1 has been implicated as a regulator of multiple biological processes and signaling pathways, including the control of cell-cycle arrest, p53-mediated apoptosis, Wnt signaling, transforming growth factor (TGF)-beta signaling, ras-induced cell (...)

• FLCN
  27 November 2004

  folliculin, FLCL

• MUTYH
  20 November 2003

  DNA glycosylase MYH, homolog of E. coli MutY; mutY homolog (E. coli)

0 | 10