Inactivated in tumors

Articles

• MUTYH
  20 November 2003

  DNA glycosylase MYH, homolog of E. coli MutY; mutY homolog (E. coli)

• ADAM3A
  23 November 2011

  Pathology
  Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas. (#21138945#)
  References
  Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas. Barrow J, Adamowicz-Brice M, Cartmill M, MacArthur D, Lowe J, Robson K, Brundler MA, Walker DA, Coyle B, Grundy R. Neuro Oncol. 2011 Feb;13(2):212-22. PMID: (...)

• CDKN2A
  12 December 2003

  p16 protein, P16, INK4, INK4A, CYCLIN-DEPENDENT KINASE INHIBITOR 2A, CDKN2A
  Definition: p16 is an inhibitor of cyclin-dependent kinases. p16INK4 gene encodes a specific inhibitor of cyclin-dependent kinase 4 (CDK4). p16INK4a binds to cyclin D-CDK4 and promotes the inhibitory effects of RB.
  Since the CDK4/cyclin D complex propels a cell to go through the G1 check point of the cell cycle, a critical phase of cell division, alteration of the p16INK4 gene could lead a cell to uncontrolled (...)

• AKT1
  24 November 2004

  Proteine kinase B, PKB, PKB-alpha, Proteine kinase B-alpha

• AIM2
  31 August 2007

  AIM2 encodes a deduced 344-amino acid protein that contains a conserved sequence domain of approximately 200 amino acids shared with interferon-inducible genes as IFI16 (MIM.147586) and MNDA (MIM.159553) as well as a tyrosine kinase phosphorylation site.
  Northern blot analysis revealed expression of a 2-kb AIM2 transcript in spleen, small intestine, and peripheral blood leukocytes as well as a slightly larger transcript in testis. Overexpression of AIM2 reversed the tumorigenic phenotype (...)

• DLEC1
  3 September 2007

  Deleted in Lung and Esophageal Cancer 1

• CTNNB1
  11 July 2003

  CTNNB1, cadherin-associated protein, beta-catenin PO WP
  Definition: Protein encoded by CTNNB1 gene, coordinates cell–cell adhesion and gene transcription.
  Function
  Part of Wnt signalling pathway, highly conserved pathway with critical role in embryologic development (Dev Cell 2009;17:9), carcinogenesis and epithelial-to-mesenchymal transition.
  Upon Wnt activation, β-catenin is translocated from membrane (where it interacts with E-cadherin) to cytoplasm and nucleus, where it (...)

• TGFBR2
  3 September 2007

  transforming growth factor beta (TGFB) Type II receptor (TGFBR2)

• PTEN
  25 July 2003

  Phosphatase and tensin homolog, MMAC1

• PRDM2
  19 March 2006

  RIZ1

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