Amplified in tumors

Articles

• DYRK2
  30 September 2008

  Human fetal brain DYRK2 (GenBank Y13493) cDNAs encode 2 isoforms: a deduced 528-amino acid protein and a protein containing 73 additional amino acids at the N terminus.
  The DYRK2 proteins contain a canonical kinase domain located between a large N-terminal region and a short C-terminal extension, and features specific to DYRK-related kinases.
  DYRK2 shares 46% identity with DYRK1 in the catalytic domain, but lacks the striking sequence motifs identified in DYRK1.
  The DYRK2 and DYRK3 (...)

• CD44
  17 June 2003

  Definition: CD44 is a well characterized cellular adhesion molecule involved in several human malignancies. It is encoded by a gene located at 11p12-13.
  Functions
  CD44 binds hyaluronan. Mucin-like glycoproteins, such as heparan sulfate, serve as ligands for the leukocyte adhesion molecule called CD44. These glycoproteins are found in the extracellular matrix and on cell surfaces.
  CD44 is expressed by lymphoid cells, and is involved in the extravasation of lymphoid cells, it does not (...)

• EZH2
  23 January 2006

  Enhancer of zeste homolog 2 (EZH2) WKP
  Definition: Ezh2 is a polycomb group protein. EZH2 is known to function in histone methylation, thereby regulating gene expression.
  Ezh2-containing complex has been given an additional role in cellular regulation. Cytosolic Ezh2 methyltransferase complexes were shown to associate with Vav1 and control receptor-induced actin polymerization and proliferation in a methylation-dependent manner.
  Overall, lysine methylation is a posttranslational (...)

• ESR1
  12 December 2003

  ER-alpha, estrogen receptor alpha

• MYCN
  18 April 2005

  NMYC, N-MYC

• GLI1
  28 June 2004

  Ci, Cubitus interruptus homolog GLI1, glioma-associated oncogen homolog GLI, GLI
  Definition: GLI is a Zinc Finger transcription factor that is the transcription factor of the Hedgehog signaling pathway.
  Gli code hypothesis (#17845852#)
  The Gli code hypothesis postulates that the three vertebrate Gli transcription factors act together in responding cells to integrate intercellular Hedgehog (Hh) and other signaling inputs, resulting in the regulation of tissue pattern, size and shape.
  Hh (...)

• MITF
  14 May 2005

  MIT
  MITF code for a basic helix-loop-helix zipper protein that functions as a homodimeric transcription factor.
  Microphthalmia-associated transcription factor (MITF) acts as a master regulator of melanocyte development, function and survival by modulating various differentiation and cell-cycle progression genes.
  MITF is placed between instructing melanocytes towards terminal differentiation and/or pigmentation and, alternatively, promoting malignant behavior.
  MITF (microphthalmia (...)

• STIM2
  6 September 2007

  STIM2 is an inhibitor of STIM1 (MIM.605921)-mediated store-operated Ca(2+) (SOC) entry.
  Pathology
  STIM2 is overexpressed in glioblastoma multiforme (#17002787#)
  References
  Ruano Y, Mollejo M, Ribalta T, Fiano C, Camacho FI, Gomez E, de Lope AR, Hernandez-Moneo JL, Martinez P, Melendez B. Identification of novel candidate target genes in amplicons of Glioblastoma multiforme tumors detected by expression and CGH microarray profiling. Mol Cancer. 2006 Sep 26;5:39. PMID: (...)

• KIF14
  6 September 2007

  KIF14 is a member of the kinesin superfamily of microtubule-associated motors (KIFs) that play important roles in intracellular transport and cell division.
  Pathology
  located in 1q32.1 amplification (62%) (positively associated with 6p gain and maybe MYCN gain) (#17099872#)
  KIF14 (kinesin family member 14) is an overexpressed candidate oncogene in the 1q31.3-1q32.1 minimal region of genomic gain in breast cancer cell lines.
  KIF14 overexpression is a negative predictor of grade and (...)

• TRIO
  11 September 2007

  Structure
  The TRIO protein contains 3 functional domains: a serine/threonine kinase domain and 2 guanine nucleotide exchange factor (GEF) domains for the family of Rho-like GTPases, specific for Rac1 (MIM.602048) and RhoA (MIM.165390). These functional domains suggest that this enzyme may play a key role in several signaling pathways that control cell proliferation.
  Pathology
  Copy number gains and high-level amplifications of the short arm of chromosome 5 are frequently observed in soft (...)

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