Amplified in tumors

Articles

• GLI1
  28 June 2004

  Ci, Cubitus interruptus homolog GLI1, glioma-associated oncogen homolog GLI, GLI
  Definition: GLI is a Zinc Finger transcription factor that is the transcription factor of the Hedgehog signaling pathway.
  Gli code hypothesis (#17845852#)
  The Gli code hypothesis postulates that the three vertebrate Gli transcription factors act together in responding cells to integrate intercellular Hedgehog (Hh) and other signaling inputs, resulting in the regulation of tissue pattern, size and shape.
  Hh (...)

• EZH2
  23 January 2006

  Enhancer of zeste homolog 2 (EZH2) WKP
  Definition: Ezh2 is a polycomb group protein. EZH2 is known to function in histone methylation, thereby regulating gene expression.
  Ezh2-containing complex has been given an additional role in cellular regulation. Cytosolic Ezh2 methyltransferase complexes were shown to associate with Vav1 and control receptor-induced actin polymerization and proliferation in a methylation-dependent manner.
  Overall, lysine methylation is a posttranslational (...)

• DYRK2
  30 September 2008

  Human fetal brain DYRK2 (GenBank Y13493) cDNAs encode 2 isoforms: a deduced 528-amino acid protein and a protein containing 73 additional amino acids at the N terminus.
  The DYRK2 proteins contain a canonical kinase domain located between a large N-terminal region and a short C-terminal extension, and features specific to DYRK-related kinases.
  DYRK2 shares 46% identity with DYRK1 in the catalytic domain, but lacks the striking sequence motifs identified in DYRK1.
  The DYRK2 and DYRK3 (...)

• YEATS4
  30 September 2008

  Definition: YEATS4 is a transcription factor.
  Shown to inhibit p53 transactivation activity and decrease the p53 proapoptotic response, the inhibition of YEATS4 results in p53 stabilization and activation.
  Pathology
  YEATS4 is a transcription factor amplified in human gliomas.
  YEATS4 (GAS41) as a novel oncogene important in the pathogenesis of WDLPS/DDLPS (well-differentiared liposarcoma/dedifferentiated liposarcoma).
  The functional impairment of the p53 pathway plays a crucial role (...)

• ERBB2
  11 February 2006

  ERBB2 ; CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1; c-erbb2
  The oncogene originally called HER/NEU was derived from rat neuro/glioblastoma cell lines. It encodes a tumor antigen, p185, which is serologically related to EGFR, the epidermal growth factor receptor (MIM.131550).
  ERBB2 encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases (ERBBs).
  ERBB2 has no ligand binding domain of its own and therefore cannot bind growth factors. (...)

• MITF
  14 May 2005

  MIT
  MITF code for a basic helix-loop-helix zipper protein that functions as a homodimeric transcription factor.
  Microphthalmia-associated transcription factor (MITF) acts as a master regulator of melanocyte development, function and survival by modulating various differentiation and cell-cycle progression genes.
  MITF is placed between instructing melanocytes towards terminal differentiation and/or pigmentation and, alternatively, promoting malignant behavior.
  MITF (microphthalmia (...)

• MYCN
  18 April 2005

  NMYC, N-MYC

• GPC5
  21 September 2004

  glypican-5, GLYPICAN 5, GPC5

• PDGFRA
  12 December 2003

  platelet-derived growth factor receptor (PDGFR) alpha, PDGFR-alpha

• KIF14
  6 September 2007

  KIF14 is a member of the kinesin superfamily of microtubule-associated motors (KIFs) that play important roles in intracellular transport and cell division.
  Pathology
  located in 1q32.1 amplification (62%) (positively associated with 6p gain and maybe MYCN gain) (#17099872#)
  KIF14 (kinesin family member 14) is an overexpressed candidate oncogene in the 1q31.3-1q32.1 minimal region of genomic gain in breast cancer cell lines.
  KIF14 overexpression is a negative predictor of grade and (...)

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