Definition: YEATS4 is a transcription factor.
Shown to inhibit p53 transactivation activity and decrease the p53 proapoptotic response, the inhibition of YEATS4 results in p53 stabilization and activation.
Pathology
YEATS4 is a transcription factor amplified in human gliomas.
YEATS4 (GAS41) as a novel oncogene important in the pathogenesis of WDLPS/DDLPS (well-differentiared liposarcoma/dedifferentiated liposarcoma).
The functional impairment of the p53 pathway plays a crucial role (...)
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Amplified in tumors
Articles
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YEATS4
30 September 2008 -
DYRK2
30 September 2008Human fetal brain DYRK2 (GenBank Y13493) cDNAs encode 2 isoforms: a deduced 528-amino acid protein and a protein containing 73 additional amino acids at the N terminus.
The DYRK2 proteins contain a canonical kinase domain located between a large N-terminal region and a short C-terminal extension, and features specific to DYRK-related kinases.
DYRK2 shares 46% identity with DYRK1 in the catalytic domain, but lacks the striking sequence motifs identified in DYRK1.
The DYRK2 and DYRK3 (...) -
IKBKE
29 August 2008Pathology
amplified by amp(1)(q32.1) in mammary carcinomas (breast cancer) -
REL
9 January 2007c-rel
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EZH2
23 January 2006Enhancer of zeste homolog 2 (EZH2) WKP
Definition: Ezh2 is a polycomb group protein. EZH2 is known to function in histone methylation, thereby regulating gene expression.
Ezh2-containing complex has been given an additional role in cellular regulation. Cytosolic Ezh2 methyltransferase complexes were shown to associate with Vav1 and control receptor-induced actin polymerization and proliferation in a methylation-dependent manner.
Overall, lysine methylation is a posttranslational (...) -
MYCN
18 April 2005NMYC, N-MYC
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TRIO
11 September 2007Structure
The TRIO protein contains 3 functional domains: a serine/threonine kinase domain and 2 guanine nucleotide exchange factor (GEF) domains for the family of Rho-like GTPases, specific for Rac1 (MIM.602048) and RhoA (MIM.165390). These functional domains suggest that this enzyme may play a key role in several signaling pathways that control cell proliferation.
Pathology
Copy number gains and high-level amplifications of the short arm of chromosome 5 are frequently observed in soft (...) -
PDGFRA
12 December 2003platelet-derived growth factor receptor (PDGFR) alpha, PDGFR-alpha
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GLI1
28 June 2004Ci, Cubitus interruptus homolog GLI1, glioma-associated oncogen homolog GLI, GLI
Definition: GLI is a Zinc Finger transcription factor that is the transcription factor of the Hedgehog signaling pathway.
Gli code hypothesis (#17845852#)
The Gli code hypothesis postulates that the three vertebrate Gli transcription factors act together in responding cells to integrate intercellular Hedgehog (Hh) and other signaling inputs, resulting in the regulation of tissue pattern, size and shape.
Hh (...) -
NACC1
26 May 2011nucleus accumbens associated 1, BEN and BTB (POZ) domain containing