Cancer gene

Articles

• NUP214
  19 June 2007

  CAN/Nup214

• ACVR1B
  18 November 2003

  ACVRLK4, ALK4

• CHEK1
  12 March 2006

  CHK1

• FBXW7
  31 January 2008

  cdc4, archipelago, F-Box and WD40 domain protein 7, hCDC4, homolog of drosophila Archipelago

• FUS
  14 October 2003

  TLS, translocated in liposarcoma

• MADH3
  10 November 2003

  SMAD3
  Pathology
  EWSR1-MADH3 / SMAD3 Gene Fusions in a Group of Acral Fibroblastic Spindle Cell Neoplasms. (#29309308#) https://twitter.com/ScottBikeethan/status/1150821877386027008
  References
  Novel EWSR1-SMAD3 Gene Fusions in a Group of Acral Fibroblastic Spindle Cell Neoplasms. Kao YC, Zhang L, Sung YS, Suurmeijer AJH, Antonescu CR. Am J Surg Pathol. 2018 Jan 5. doi:10.1097/PAS.0000000000001002. PMID: #29309308#
  Roberts AB, Russo A, Felici A, Flanders KC. Smad3: a key player in (...)

• CIC
  30 January 2008

  Protein capicua homolog CIC
  Definition: CIC, a human homolog of Drosophila capicua which encodes a high mobility group box transcription factor, is fused to a double homeodomain gene DUX4 as a result of a recurrent chromosomal translocation t(4;19)(q35;q13).
  Molecular biology
  CIC-DUX4 fusion gene between DUX4 at 4q35 (MIM.606009) and CIC at 19q35 by t(4;19)(q35;q13) (#16717057#) in Ewing-like sarcoma
  CIC-rearranged undifferentiated round-cell sarcoma with exclusive spindled (...)

• DUX4
  30 January 2008

  Molecular biology
  CIC-DUX4 gen fusion in Ewing-like sarcoma
  Ewing-like sarcomas with t(4;19)(q35;q13)
  Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation.
  fusion gene between DUX4 at 4q35 (MIM.606009) and CIC at 19q35 by t(4;19)(q35;q13) (#16717057#)
  CIC, a human homolog of Drosophila capicua which encodes a high mobility group box transcription factor, is fused to a double homeodomain gene DUX4 as a result of a (...)

• TGFBR2
  3 September 2007

  transforming growth factor beta (TGFB) Type II receptor (TGFBR2)

• WIF1
  3 September 2007

  Function
  WNTs proteins are extracellular signaling molecules involved in the control of embryonic development. There are at least 2 families of secreted inhibitors of WNT signaling:
  the secreted frizzled-related protein family (as SFRP1; MIM.604156), all of which have an N-terminal cysteine-rich domain and are transmembrane receptors;
  and the Dickkopf (German for ’big head,’ or ’stubborn’) family (as DKK1; MIM. 605189).
  Pathology
  WIF1/HMGA2 fusion in pleomorphic adenomas (#17171686#) (...)

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