Cancer gene

Articles

• FHIT
  5 March 2006

  Pathology
  The constitutional translocation t(3;8)(p14.2;q24.1) fuses FHIT at 3p14 with the patched-related gene TRC8 at 8q24.1 (#9689122#) with formation of the TRC8/FHIT fusion gene). It predisposes to
  hereditary renal clear cell carcinoma (#17539022#)
  hereditary renal clear cell carcinoma and non-medullary thyroid cancer (#470981#, #12522559#, #17539022#)
  TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway (#12032852#)
  References (...)

• NOTCH1
  11 June 2003

  Notch1

• ALK
  19 June 2003

  Locus: 2p23. AGCOH OMIM
  Cytogenetics
  t(2;17)(p23;q23)
  Pathology
  ALK rearrangements - ALK fusion
  Chromosomal rearrangements involving the anaplastic lymphoma kinase gene (ALK) at 2p23 result in fusion with various partner genes leading to aberrant production of oncogenic protein products in multiple tumor types.
  In tumorigenesis, the ALK gene at 2p23 is known to be fused to NPM, TPM3, TPM4, TFG, ATIC, CLTC, MSN, and ALO17.
  ALK-ATIC by inv(2)(p23q35) in IMF (#12939746#) (...)

• TCF3
  8 June 2004

  E2A ITF1

• FUS
  14 October 2003

  TLS, translocated in liposarcoma

• CSPG2
  28 February 2008

  Pathology
  translocation t(5;8) involving the CSPG2 and PTK2B genes in a dermatofibrosarcoma protuberans without the COL1A1-PDGFB fusion (#18253748#)
  References
  Bianchini L, Maire G, Guillot B, Joujoux JM, Follana P, Simon MP, Coindre JM, Pedeutour F. Complex t(5;8) involving the CSPG2 and PTK2B genes in a case of dermatofibrosarcoma protuberans without the COL1A1-PDGFB fusion. Virchows Arch. 2008 Feb 6; PMID: (...)

• PRDM16
  3 September 2007

  MEL1

• PVRL2
  29 August 2007

  Function
  Entry of the poliovirus into permissive cells is dependent on the expression of a specific receptor, the poliovirus receptor (PVR; 173850), which is an integral membrane glycoprotein.
  Its extracellular region exhibits 3 immunoglobulin-like domains. Two integral forms, PVR-alpha and PVR-delta, and 2 soluble forms, PVR-beta and PVR-gamma, are lacking a transmembrane region generated by alternative splicing of mRNA. The normal cellular function of PVR is unknown.
  Pathology (...)

• WIF1
  3 September 2007

  Function
  WNTs proteins are extracellular signaling molecules involved in the control of embryonic development. There are at least 2 families of secreted inhibitors of WNT signaling:
  the secreted frizzled-related protein family (as SFRP1; MIM.604156), all of which have an N-terminal cysteine-rich domain and are transmembrane receptors;
  and the Dickkopf (German for ’big head,’ or ’stubborn’) family (as DKK1; MIM. 605189).
  Pathology
  WIF1/HMGA2 fusion in pleomorphic adenomas (#17171686#) (...)

• NBS1
  19 August 2004

  Pathology
  germline mutations in the Nijmegen breakage syndrome (NBS)
  increased cancer risk of heterozygotes with NBS1 germline mutations (#15185344#)
  See also
  FANC/BRCA1/BRCA2/ATM/NBS1 signaling pathway
  References
  Kobayashi J, Antoccia A, Tauchi H, Matsuura S, Komatsu K. NBS1 and its functional role in the DNA damage response. DNA Repair (Amst). 2004 Aug-Sep;3(8-9):855-61. PMID: (...)

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