Involved in translocations

Articles

• ETV6
  3 June 2004

  TEL (translocation ets leukemia)

• PCM1
  23 January 2006

  pericentriolar material 1

• HIP1
  22 January 2006

  Definition: HIP1 is a peptide that shares similarity to the budding yeast Sla2p, which is involved in cytoskeleton function. HIP1 interacts with huntingtin-interacting protein interactor (HIPPI), which is homologous to the C. reinhardtii intraflagellar transport IFT.
  The identification of the huntingtin-interacting protein (HIP1)provides further supporting evidence for the role of huntingtin HD in the organization of the cytoskeleton and microtubule-based transport.
  Pathology (...)

• NUMA1
  23 January 2006

  The NUMA1 protein was one of the first to be described as a cell cycle-related protein based on a distinct immunofluorescent staining pattern: in interphase, NUMA1 is present throughout the nucleus, and in mitosis, it localizes to the spindle apparatus.
  The full-length NUMA cDNA predicts a protein with an unusually long coiled-coil region.
  Pathology
  NUMA1/RARA fusion gene by t(11;17)(q13;q21). in acute promyelocytic leukemia (APL) (NUMA1 at 17q13 and RARA at 17q21).
  Some patients (...)

• FOXO1
  2 February 2007

  FKHR, FOXOA1
  Pathology
  PAX3-FOXO1 or PAX7-FOXO1 fusion genes in alveolar rhabdomyosarcoma
  Alveolar rhabdomyosarcoma (ARMS) is an aggressive neoplasm with unique t(2;13)(q35;q14) or t(1;13)(p36;q14) chromosomal translocations, resulting in PAX3/FOXO1 and PAX7/FOXO1 fusion genes, in approximately 80% of cases.
  These translocations and their gene fusions have not been identified in other neoplasms, making their identification an attractive target for applying ancillary diagnostic (...)

• TCF12
  18 January 2006

  HTF4

• LCK
  18 January 2006

  The LCK gene encodes p56(LCK), a nonreceptor protein-tyrosine kinase of the SRC (MIM.190090) oncogene family that is involved in transduction of T-cell receptor (TCR; MIM.186880)-mediated activation.
  The p56(LCK) protein is anchored to the plasma membrane and interacts with the intracellular domains of CD4 (MIM.186940)/CD8 (MIM.186910) coreceptors.
  It is composed of 4 SRC homology (SH) domains that are variably conserved among members of the SRC family (Germani et al., 2003).
  Pathology (...)

• ATL
  18 January 2006

  TCL2

• TCRA
  18 January 2006

  TCRA at 14q11

• NCOA1
  4 February 2007

  NUCLEAR RECEPTOR COACTIVATOR 1; STEROID RECEPTOR COACTIVATOR 1; SRC1
  Pathology
  t(2;2)(q35;p23) creating a PAX3/NCOA1 fusion gene (PAX3 at 2q35 and NCOA1 at 2p23) in alveolar rhabdomyosarcoma (#15313887#) - NCOA1-PAX3 fusion gene by t(2;2)(q35;p23) (PAX3 at 2q35 and NCOA1 at 2p23) (#15313887#)
  Genetic alterations of SRC1 are rare in prostate cancer. The nuclear protein accumulation of SRC1 seems to be mildly increased in androgen ablation resistant prostate cancers (#16894533#) (...)

0 | 10 | 20 | 30 | 40 | 50 | 60 | 70 | 80 | ... | 140