Involved in translocations

Articles

• ETV6
  3 June 2004

  TEL (translocation ets leukemia)

• CXCR7
  17 May 2007

  RDC1, chemokine CXC motif receptor 7
  Pathology
  HMGA2/CXCR7 fusion gene in lipomas CXCR7 at 2q37 HMGA2 at 12q14
  CXCL12-CXCR7 axis contributes to the invasive phenotype of pancreatic cancer.
  (#27542220#)
  See also
  CXCRs (chemokine CXC motif receptors)
  References
  Broberg K, Zhang M, Strombeck B, Isaksson M, Nilsson M, Mertens F, Mandahl N, Panagopoulos I. Fusion of RDC1 with HMGA2 in lipomas as the result of chromosome aberrations involving 2q35-37 and 12q13-15. Int J Oncol. 2002 (...)

• EML4
  23 July 2007

  Pathology
  EML4-ALK fusion gene in non-small-cell lung cancer (6.7% of NSCLC) (#17625570#)
  See also
  EMLs: EML1, EMl2, EML3
  References
  Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, Fujiwara SI, Watanabe H, Kurashina K, Hatanaka H, Bando M, Ohno S, Ishikawa Y, Aburatani H, Niki T, Sohara Y, Sugiyama Y, Mano H. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007 Jul 11; PMID: #17625570#
  Heidebrecht, H. J.; Buck, F.; (...)

• NEAT1
  20 August

  Microphthalmia-associated transcription factor (MiT) family translocation renal cell carcinoma harbors variable gene fusions involving either TFE3 or TFEB genes.
  Multiple 5’ fusion partners for TFE3 have been reported, including ASPSCR1, CLTC, DVL2, LUC7L3, KHSRP, PRCC, PARP14, NONO, SFPQ1, MED15, RBM10, KAT6A and NEAT1. Each of these fusion genes activates TFE3 transcription which can be detected by immunostaining.
  Open references
  NEAT1-TFE3 and KAT6A-TFE3 renal cell carcinomas, new (...)

• BCOR
  1 January 2011

  BCL6 corepressor; FLJ20285, KIAA1575
  The BCOR-CCNB3 fusion gene, resulting from a chromosome X paracentric inversion, was described in translocation-negative ’Ewing-like’ sarcomas arising in bone and soft tissue.
  Pathology
  BCOR-CCNB3 gene fusion in Ewing-like sarcoma . (#22387997#)
  CCNB3 immunohistochemistry is a powerful diagnostic marker for this subgroup of sarcoma and that overexpression of BCOR-CCNB3 or of truncated CCNB3 activates S phase in NIH3T3 cells.
  The intrachromosomal (...)

• ATIC
  22 August 2004

  Pathology
  ATIC/ALK fusion protein by inv(2)(p23q35) in anaplastic large cell lymphoma (ALCL)

• BCR
  7 June 2004

  Pathology
  BCR/ABL fusion gene in B-lineage acute lymphoblastic leukemia by t(9;22)(q34;q11)
  BCR expression is decreased in meningiomas showing loss of heterozygosity of 22q (22q11 LOH) (#18474292#)
  References
  Wozniak K, Piaskowski S, Gresner SM, Golanska E, Bieniek E, Bigoszewska K, Sikorska B, Szybka M, Kulczycka-Wojdala D, Zakrzewska M, Zawlik I, Papierz W, Stawski R, Jaskolski DJ, Och W, Sieruta M, Liberski PP, Rieske P. BCR expression is decreased in meningiomas showing loss of (...)

• NCOA1
  4 February 2007

  NUCLEAR RECEPTOR COACTIVATOR 1; STEROID RECEPTOR COACTIVATOR 1; SRC1
  Pathology
  t(2;2)(q35;p23) creating a PAX3/NCOA1 fusion gene (PAX3 at 2q35 and NCOA1 at 2p23) in alveolar rhabdomyosarcoma (#15313887#) - NCOA1-PAX3 fusion gene by t(2;2)(q35;p23) (PAX3 at 2q35 and NCOA1 at 2p23) (#15313887#)
  Genetic alterations of SRC1 are rare in prostate cancer. The nuclear protein accumulation of SRC1 seems to be mildly increased in androgen ablation resistant prostate cancers (#16894533#) (...)

• FOXO1
  2 February 2007

  FKHR, FOXOA1
  Pathology
  PAX3-FOXO1 or PAX7-FOXO1 fusion genes in alveolar rhabdomyosarcoma
  Alveolar rhabdomyosarcoma (ARMS) is an aggressive neoplasm with unique t(2;13)(q35;q14) or t(1;13)(p36;q14) chromosomal translocations, resulting in PAX3/FOXO1 and PAX7/FOXO1 fusion genes, in approximately 80% of cases.
  These translocations and their gene fusions have not been identified in other neoplasms, making their identification an attractive target for applying ancillary diagnostic (...)

• MTG16
  29 September 2008

  Pathology
  Transcription co-repressor MTG16 modulates colitis and tumor development in inflammatory carcinogenesis. MTG16 is a tumor suppressor in colitis-associated carcinoma. doi:10.1172/jci.insight.78210.
  RUNX1-MTG16 fusion gene in acute myeloblastic leukemia (#18656694#) The significant homology between MGT16 and MTG8 suggests that the RUNX1-MTG16 fusion gene induced by the t(16;21)(q24;q22) is a variant of the RUNX1-MTG8 that shares similar activity.
  References
  De Braekeleer E, (...)

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