Involved in translocations

Articles

• HMGA2
  27 October 2004

  HMGI-C, HMGI-C

• FIP1L1
  9 February 2006

  Pathology
  PDGFRA/FIP1L1 gene fusion in
  chronic eosinophilic leukemia (idiopathic hypereosinophilic syndrome) (MIM.607685)
  eosinophilia-associated acute myeloid leukemia (#17377585#)
  lymphoblastic T-cell lymphoma (#17377585#)
  References
  Vigna E, Lucia E, Gentile M, Mazzone C, Bisconte MG, Gentile C, Armentano A, Ottaviani E, Rondoni M, Martinelli G, Morabito F. PDGFRalpha/FIP1L1-positive chronic eosinophilic leukemia presenting with retro-orbital localization: efficacy of imatinib (...)

• ALK
  19 June 2003

  Locus: 2p23. AGCOH OMIM
  Cytogenetics
  t(2;17)(p23;q23)
  Pathology
  ALK rearrangements - ALK fusion
  Chromosomal rearrangements involving the anaplastic lymphoma kinase gene (ALK) at 2p23 result in fusion with various partner genes leading to aberrant production of oncogenic protein products in multiple tumor types.
  In tumorigenesis, the ALK gene at 2p23 is known to be fused to NPM, TPM3, TPM4, TFG, ATIC, CLTC, MSN, and ALO17.
  ALK-ATIC by inv(2)(p23q35) in IMF (#12939746#) (...)

• MORF
  9 June 2003

  MYST4, monocytic leukemia zinc finger protein-related factor

• NCOA1
  4 February 2007

  NUCLEAR RECEPTOR COACTIVATOR 1; STEROID RECEPTOR COACTIVATOR 1; SRC1
  Pathology
  t(2;2)(q35;p23) creating a PAX3/NCOA1 fusion gene (PAX3 at 2q35 and NCOA1 at 2p23) in alveolar rhabdomyosarcoma (#15313887#) - NCOA1-PAX3 fusion gene by t(2;2)(q35;p23) (PAX3 at 2q35 and NCOA1 at 2p23) (#15313887#)
  Genetic alterations of SRC1 are rare in prostate cancer. The nuclear protein accumulation of SRC1 seems to be mildly increased in androgen ablation resistant prostate cancers (#16894533#) (...)

• FOX01A
  25 November 2003

  FKHR

• MLL
  19 April 2004

  TRX1, humona homolog of drosophila trithorax
  The MLL gene is homologous to Drosophila trithorax and is likewise involved in embryo pattern formation. The MLL gene encodes a DNA-binding protein that methylates histone H3 lysine 4 (H3K4), and positively regulates gene expression including multiple Hox genes.
  Pathology
  MLL-associated leukemias Translocations that involve the mixed lineage leukaemia (MLL) gene identify a unique group of acute leukaemias, and often predict a poor prognosis. (...)

• MESDC2
  15 June 2005

  Pathology
  MESDC2/SENP1 fusion gene by constitutional t(12;15)(q13;q25) pat in sacrococcygeal teratoma (#15917269#, #12165446#)

• SENP1
  15 June 2005

  Pathology
  MESDC2/SENP1 fusion gene by constitutional t(12;15)(q13;q25) pat (#15917269#, #12165446#) in sacrococcygeal teratoma

• HOXA13
  20 June 2005

  Pathology
  triphalangeal thumb-brachyectrodactyly syndrome (#12382951#)
  hand-foot-genital syndrome
  polyalanine repeat expansion
  HOXA genes in T-cell acute lymphoblastic leukemia (T-ALL)
  HOXA13 rearrangement and surexpression in T-cell acute lymphoblastic leukemia (T-ALL) (#16804919#)
  See also
  polyalanine repeat expansions
  References
  Su X, Drabkin H, Clappier E, Morgado E, Busson M, Romana S, Soulier J, Berger R, Bernard OA, Lavau C. Transforming potential of the T-cell acute (...)

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