Molecular processes

Articles

• mutation mechanisms
  26 May 2004

  Exemples
  splice site mutation and exon skipping
  LINE insertion
  retroviral insertion

• DNA damage sensing
  3 March 2006

  DNA damage sensing
  To function properly, cell-cycle checkpoints require sensors of DNA damage, signal transducers, and effector molecules. The sensors and transducers of DNA damage appear to be similar for the G1/S and G2/M checkpoints.
  They include, as sensors, proteins of the RAD family and ataxia telangiectasia mutated (ATM) and as transducers, the CHK kinase families. The checkpoint effector molecules differ, depending on the cell-cycle stage at which they act.
  In the G1/S (...)

• SUMOylation
  13 February 2006

  sumoylation

• RNA silencing
  24 May 2005

  Definition: Small non-coding RNAs have rapidly emerged as important contributors to gene regulation. To carry out their biological functions, these small RNAs require a unique class of proteins called Argonautes.
  RNA silencing was discovered in plants as a mechanism whereby invading nucleic acids, such as transgenes and viruses, are silenced through the action of small (20-26 nt) homologous RNA molecules.
  Endogenous silencing pathways have important roles in gene regulation at the (...)

• protein refolding
  16 February 2006

  Videos
  Protein folding
  References
  Soto C: Protein misfolding and disease; protein refolding and therapy. FEBS Lett 498:204, 2001.

• protein aggregation
  7 March 2004

  protein aggregates

• RNA translation
  30 November 2003

  Pathology
  translation diseases
  Wolcott-Rallison syndrome
  Reticulum endoplasmic
  reticulum endoplasmic stress
  The list of genetic diseases caused by mutations that affect mRNA translation is rapidly growing. Although protein synthesis is a fundamental process in all cells, the disease phenotypes show a surprising degree of heterogeneity.
  Studies of some of these diseases have provided intriguing new insights into the functions of proteins involved in the process of translation; for (...)

• proteic maturation
  27 January 2006

  protein maturation

• protein glycosylation
  27 January 2005

  proteic glyscosylation

• protein sorting
  30 November 2003

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