Molecular processes

Articles

• RNA translation
  30 November 2003

  Pathology
  translation diseases
  Wolcott-Rallison syndrome
  Reticulum endoplasmic
  reticulum endoplasmic stress
  The list of genetic diseases caused by mutations that affect mRNA translation is rapidly growing. Although protein synthesis is a fundamental process in all cells, the disease phenotypes show a surprising degree of heterogeneity.
  Studies of some of these diseases have provided intriguing new insights into the functions of proteins involved in the process of translation; for (...)

• overexpression
  7 October 2005

  genic overexpression

• promoter swapping
  18 August 2004

  Exemples
  promoter swapping between the genes for zinc finger protein PLAG1 and beta-catenin CTNNB1 in pleiomorphic adenoma with t(3;8)(p21;q12) translocation (#9020842#)
  PLAG1 at 8q12 and LIFR promoter at 5p13 PLAG1 gene overexpression under control of the LIFR promoter (#9525740#) in pleomorphic adenomas (#9525740#)
  PLAG1 in lipoblastomas
  USP6 in aneurysmal cyst of bones
  See also
  tumoral chromosomal (...)

• cotranslational protein processing
  1 February 2006

  References
  Drenth JP, Martina JA, van de Kerkhof R, Bonifacino JS, Jansen JB. Polycystic liver disease is a disorder of cotranslational protein processing. Trends Mol Med. 2005 Jan;11(1):37-42. PMID: #15649821#

• proteic maturation
  27 January 2006

  protein maturation

• bacterial invasion
  30 November 2003

  References
  Cossart P, Pizarro-Cerda J, Lecuit M. Invasion of mammalian cells by Listeria monocytogenes : functional mimicry to subvert cellular functions. Trends Cell Biol. 2003 Jan ;13(1):23-31. PMID : #12480337#

• unfolded protein response
  14 January 2006

  UPR, unfolded-protein response
  The endoplasmic reticulum (ER) responds to the accumulation of unfolded proteins in its lumen (ER stress) by activating intracellular signal transduction pathways, cumulatively called the unfolded protein response (UPR).
  Together, at least three mechanistically distinct arms of the UPR regulate the expression of numerous genes that function within the secretory pathway but also affect broad aspects of cell fate and the metabolism of proteins, amino acids and (...)

• transcriptional derepression
  2 July 2004

  Pathology
  Familial Alzheimer disease
  Rett syndrome
  Klippel-Trenaunay syndrome
  facioscapulohumeral muscular dystrophy
  References
  Gabellini D, Green MR, Tupler R. When enough is enough: genetic diseases associated with transcriptional derepression. Curr Opin Genet Dev. 2004 Jun;14(3):301-7. PMID: #15172674#

• transcription elongation
  2 July 2004

  References
  Belotserkovskaya R, Reinberg D. Facts about FACT and transcript elongation through chromatin. Curr Opin Genet Dev. 2004 Apr;14(2):139-46. PMID: #15196460#

• antibody class switching
  19 August 2004

  References
  Kaminski DA, Stavnezer J. Antibody class switching: uncoupling S region accessibility from transcription. Trends Genet. 2004 Aug;20(8):337-40. PMID: #15262403#

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