Molecular processes

Articles

• isoprenylation
  10 May 2005

  protein prenylation, prenylation

• transcription-coupled NER
  26 March 2006

  TCNER, transcription-coupled nucleotide excision repair, transcription coupled repair (TCR)

• cotranslational protein processing
  1 February 2006

  References
  Drenth JP, Martina JA, van de Kerkhof R, Bonifacino JS, Jansen JB. Polycystic liver disease is a disorder of cotranslational protein processing. Trends Mol Med. 2005 Jan;11(1):37-42. PMID: #15649821#

• RNA translation
  30 November 2003

  Pathology
  translation diseases
  Wolcott-Rallison syndrome
  Reticulum endoplasmic
  reticulum endoplasmic stress
  The list of genetic diseases caused by mutations that affect mRNA translation is rapidly growing. Although protein synthesis is a fundamental process in all cells, the disease phenotypes show a surprising degree of heterogeneity.
  Studies of some of these diseases have provided intriguing new insights into the functions of proteins involved in the process of translation; for (...)

• gene conversion
  13 May 2005

  genic conversion

• protein refolding
  16 February 2006

  Videos
  Protein folding
  References
  Soto C: Protein misfolding and disease; protein refolding and therapy. FEBS Lett 498:204, 2001.

• DNA damage sensing
  3 March 2006

  DNA damage sensing
  To function properly, cell-cycle checkpoints require sensors of DNA damage, signal transducers, and effector molecules. The sensors and transducers of DNA damage appear to be similar for the G1/S and G2/M checkpoints.
  They include, as sensors, proteins of the RAD family and ataxia telangiectasia mutated (ATM) and as transducers, the CHK kinase families. The checkpoint effector molecules differ, depending on the cell-cycle stage at which they act.
  In the G1/S (...)

• SUMOylation
  13 February 2006

  sumoylation

• antibody class switching
  19 August 2004

  References
  Kaminski DA, Stavnezer J. Antibody class switching: uncoupling S region accessibility from transcription. Trends Genet. 2004 Aug;20(8):337-40. PMID: #15262403#

• mutation mechanisms
  26 May 2004

  Exemples
  splice site mutation and exon skipping
  LINE insertion
  retroviral insertion

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