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molecular evolution

Friday 20 October 2006


Definition : The evolution has generated enormous morphological diversity in animals and one of the genetic processes that might have contributed to this is evolution of the cis-regulatory sequences responsible for the temporal and spatial expression of genes regulating embryonic development. This could be particularly relevant to pleiotropic genes with multiple independently acting regulatory modules.

It is studied by the evolutionary biology.

Loss or gain of modules enables altered expression without loss of other functions. Studies correlates differences in morphological traits between related species of Drosophila to changes in cis-regulatory sequences.

Ancestral regulatory modules have evolved to mediate different transcriptional outputs and suggest that evolution of cis-regulatory sequences might reflect a general mechanism driving evolutionary change.


- DNA tests find a world of variety, The Times, February 19, 2007


- Simpson P. The stars and stripes of animal bodies: evolution of regulatory elements mediating pigment and bristle patterns in Drosophila. Trends Genet. 2007 Jul;23(7):350-8. PMID: 17499383

- Rocha EP. The quest for the universals of protein evolution. Trends Genet. 2006 Aug;22(8):412-6. PMID: 16808987

- Sugino RP, Innan H. Selection for more of the same product as a force to enhance concerted evolution of duplicated genes. Trends Genet. 2006 Oct 10; PMID: 17045359

- Paterson AH, Chapman BA, Kissinger JC, Bowers JE, Feltus FA, Estill JC. Many gene and domain families have convergent fates following independent whole-genome duplication events in Arabidopsis, Oryza, Saccharomyces and Tetraodon. Trends Genet. 2006 Sep 15; PMID: 16979781

- Huang J, Gogarten JP. Ancient horizontal gene transfer can benefit phylogenetic reconstruction. Trends Genet. 2006 Jul;22(7):361-6. PMID: 16730850

- Dujon B. Yeasts illustrate the molecular mechanisms of eukaryotic genome evolution. Trends Genet. 2006 Jul;22(7):375-87. PMID: 16730849

- Chamary JV, Parmley JL, Hurst LD. Hearing silence: non-neutral evolution at synonymous sites in mammals. Nat Rev Genet. 2006 Feb;7(2):98-108. PMID: 16418745