RTN4R
MIM.605566 22q11
Myelin inhibitory ligands of the Nogo-66 receptor (NgR1) limit axon regeneration in the adult CNS.
Recent findings have identified additional co-receptors (functional homologues) of the trimeric NgR1 complex, post-translational modifications of the co-receptors within the cell membrane and novel Ca(2+)-dependent cytoplasmic-protein phosphorylation mechanisms.
Such unique signalling pathways provide the potential to transduce myelin-derived growth inhibitory signals to the axonal cytoskeleton.
References
Schwab JM, Tuli SK, Failli V. The Nogo receptor complex: confining molecules to molecular mechanisms. Trends Mol Med. 2006 Jul;12(7):293-7. PMID: #16723274#