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GLO1
Wednesday 31 May 2006
Glyoxalase I (EC 4.4.1.5) is a glutathione-binding protein involved in the detoxification of methylglyoxal, a byproduct of glycolysis.
GLO1 and glyoxalase II (GLO2) (MIM.138760) catalyze successive steps in the pathway. GLO1 catalyzes condensation of methylglyoxal and reduced glutathione to form S-lactoyl-glutathione; GLO2 (hydroxyacyl glutathione hydrolase) converts the latter substance to D-lactic acid and reduced glutathione.
Pathology
susceptibility to autism
anxiety
- Overexpression and silencing of glyoxalase 1 (Glo1) in brains of mice and behavioural analyses have suggested a link between Glo1 and anxiety, making Glo1 a possible novel target for anxiolytic-drug development.
References
Thornalley PJ. Unease on the role of glyoxalase 1 in high-anxiety-related behaviour. Trends Mol Med. 2006 May;12(5):195-9. PMID: 16616641
