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attention-deficit/hyperactivity disorder
MIM.143465
Monday 29 September 2003
Attention deficit hyperactivity disorder (ADHD) is a common, heritable neuropsychiatric disorder of unknown etiology.
Etiology
Rare recurrent CNVs affecting glutamatergic neurotransmission genes
- GRM5 (encoding glutamate receptor, metabotropic 5) deletions
- GRM7 deletions
- GRM8 deletions
- GRM1 duplication
Susceptibility loci
4q13.2 (15497111)
5p13 (12687500)
5q33.3 (15497111)
6q12 (15297934)
7p (12679898)
11q22 (15497111)
15q (12679898)
16p13 (also involved in autism) (12187510)
17p11 (12687500, 15497111)
Reviews
Castellanos FX, Tannock R. Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes. Nat Rev Neurosci. 2002 Aug;3(8):617-28. PMID: 12154363
References
Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. Elia J, Glessner JT, Wang K, Takahashi N et al. Nat Genet. 2011 Dec 4;44(1):78-84. PMID: 22138692
