Home > A. Molecular pathology > SMG1
SMG1
Monday 27 March 2006
SMG1 is a newly discovered member of the DNA-damage-inducible phosphatidylinositol-3-kinase-related kinase family, which also includes ATM, ATR and DNA-dependent protein kinase (DNAPK).
The SMG1 kinase might respond to both DNA damage and truncated mRNA species that might arise as a result of blocked transcription.
SMG1 is a member of the phosphatidylinositol kinase-related kinase (PIKKs) family that shows homology with phosphatidylinositol 3-kinases (PI3Ks) (MIM.171834) within their core catalytic domains.
PIKKs are distinct in that they are high molecular mass proteins that function as serine/threonine protein kinases rather than as lipid kinases.
