TIMELESS
Cellular pacemakers located in the suprachiasmatic nucleus (SCN) of the anterior hypothalamus control circadian rhythms. In Drosophila, a central clock mechanism involves the dynamic regulation of 2 genes, ’period’ (MIM.602260) and ’timeless’ (tim), which physically interact and participate in an intracellular transcriptional/translational feedback loop.
The transcription of per and tim is positively regulated by the Clock (MIM.601851) and BMAL1 (MIM.602550) proteins, which form heterodimers.