RPSKA3
The RSK (ribosomal S6 kinase) family comprises growth factor-regulated serine/threonine kinases, known also as p90(rsk).
In humans, the RSK family contains 3 closely regulated members: RSK1 (RPS6KA1) (MIM.601684), RSK2 (RPS6KA3), and RSK3 (RPS6KA2) (MIM.601685).
The highly conserved feature of all members of the RSK family is the presence of 2 nonidentical kinase catalytic domains.
RSKs are implicated in the activation of the mitogen-activated kinase cascade (MIM.176872) and the stimulation of cell proliferation (at the transition between phases G0 and G1 of the cell cycle) and differentiation.
Pathology
germline mutations in Coffin-Lowry syndrome (MIM.303600)
See also
MAPKs pathway