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NALPs

Saturday 11 February 2006

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NALP1 NALP2 NALP3 NALP4 NALP5 NALP6 NALP7

NALPs family

Most short NALPs, such as NALP7, have an N-terminal pyrin (MEFV) (MIM.608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region.

The long NALP, NALP1 (MIM.606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD).

NALPs are implicated in the activation of proinflammatory caspases (CASP1) (MIM.147678) via their involvement in multiprotein complexes called inflammasomes.