ITGB1
Beta1-integrins (ITGB1)
ITGB1
β1-containing integrins (ITGAs-ITGB1)
The β1-containing integrins (ITGAs-ITGB1) are also called VLA molecules, referring to "very late activation" molecules, because α1β1 and α2β1 were first shown to be expressed on T cells 2 to 4 weeks after repetitive stimulation in vitro. In fact, other VLA integrins are constitutively expressed on some leukocytes and rapidly induced on others.
The β1 integrins are also called CD49a-hCD29, CD49a-h referring to different α chains (α1-α8) (ITGAs) and CD29 referring to the common β1 subunit.
Most of the β1 integrins are widely expressed on leukocytes and other cells and mediate attachment of cells to extracellular matrices.
VLA-4 (α4β1 or ITGA4-ITGB1)
VLA-4 (α4β1 or ITGA4-ITGB1) is expressed only on leukocytes and can mediate attachment of these cells to endothelium by interacting with vascular cell adhesion molecule-1 (VCAM1). VLA-4 (α4β1 or ITGA4-ITGB1) is one of the principal surface proteins that mediate homing of lymphocytes to endothelium at peripheral sites of inflammation.