MADCAM1
MIM.102670 19p13.3
Tissue-specific homing of lymphocytes is regulated by interactions with the endothelium of specialized venules, such as the high endothelial venules (HEV) in lymph nodes and mucosal lymphoid tissues.
The mucosal vascular addressin (MADCAM1), a 58- to 66-kD glycoprotein adhesion receptor for lymphocytes, is selectively expressed on HEV of the mucosal lymphoid organ and on lamina propria venules and helps direct lymphocyte traffic to these mucosal tissues.