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bullous impetigo

Sunday 5 February 2006

Desmosomal cadherins are the pathophysiologic targets of autoimmune or toxin-mediated disruption in the human diseases pemphigus and bullous impetigo, including its generalized form, called staphylococcal scalded skin syndrome (SSSS).

Conformational epitopes of antidesmoglein autoantibodies in pemphigus patients sera and the specific cleavage site of desmoglein-1 (DSG1) by exfoliative toxin have been identified, implicating the N-terminal extracellular domains of the desmogleins as critical regions for controlling intercellular adhesion.

See also

- acantholysis in pemphigus
- acantholysis in staphylococcal-associated blistering disease,
- desmogleins (DSGs)
- desmosomal structure and function.


- Stanley JR, Amagai M. Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome. N Engl J Med. 2006 Oct 26;355(17):1800-10. PMID: 17065642

- Payne AS, Hanakawa Y, Amagai M, Stanley JR. Desmosomes and disease: pemphigus and bullous impetigo. Curr Opin Cell Biol. 2004 Oct;16(5):536-43. PMID: 15363804