Pathology
Defects in desmosome-mediated cell-cell adhesion can lead to tissue fragility syndromes. Both inherited and acquired diseases caused by desmosomal defects have been described.
The two organs that appear most vulnerable to these defects are the skin with its appendages, and the heart.
References
Cheng X, Den Z, Koch PJ. Desmosomal cell adhesion in mammalian development. Eur J Cell Biol. 2005 Mar;84(2-3):215-23. PMID: 15819402
