- Human pathology

Home > A. Molecular pathology > ATP


Saturday 4 February 2006

ATP is produced in two ways: oxidative phosphorylation and glycolysis

OXPHOS system and oxidative phosphorylation

The major pathway in mammalian cells is oxidative phosphorylation of adenosine diphosphate, in a reaction that results in reduction of oxygen by the electron transfer system of mitochondria.

glycolysis and the glycolytic pathway

The second is the glycolytic pathway, which can generate ATP in the absence of oxygen using glucose derived either from body fluids or from the hydrolysis of glycogen. Thus, tissues with greater glycolytic capacity (e.g., liver) have an advantage when ATP levels are falling because of inhibition of oxidative metabolism by injury.

See also

- ATPases
- ATP depletion