Humpath.com - Human pathology

Home > D. General pathology > Genetic and developmental anomalies > Genetic metabolic diseases > gangliosidoses

gangliosidoses

Wednesday 1 February 2006

Definition: Gangliosidoses are a small group of diseases due to the accumulation of gangliosides. The gangliosidoses are two distinct genetic groups of diseases. Both are autosomal recessive and affect males and females equally. It is a form of lipid storage disorder.

Ganglioside is a compound composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (AKA n-acetylneuraminic acid) linked on the sugar chain.

Types

- GM1-gangliosidosis
- GM2-gangliosidosis

See also

- genetic diseases

  • genetic metabolic diseases
    • lysosomal storage diseases

- glycolipids