complete hydatiform mole

Definition: Complete hydatidiform mole is an abnormal conceptus characterized by hydropic villi accompanied by proliferating trophoblasts. Its pathogenesis is largely unknown.

Images

 complete hydatiform mole

• https://twitter.com/luishcruzc/status/738155933801418752
• https://twitter.com/martiponi/status/874553019928596480

IHC

Androgenetic Complete Hydatiform Mole: P57- in villous stroma and cytotrophoblast whereas P57 + in extravillous trophoblast.

See also

 hydatiform mole

• partial hydatiform mole

References

 Hoffner L, Dunn J, Esposito N, Macpherson T, Surti U. P57KIP2 immunostaining and molecular cytogenetics: combined approach aids in diagnosis of morphologically challenging cases with molar phenotype and in detecting androgenetic cell lines in mosaic/chimeric conceptions.Hum Pathol. 2008 Jan;39(1):63-72. PMID: 17904617

 Maggiori MS, Peres LC. Morphological, immunohistochemical and chromosome in situ hybridization in the differential diagnosis of Hydatidiform Mole and Hydropic Abortion. Eur J Obstet Gynecol Reprod Biol. 2007 Dec;135(2):170-6. PMID: 17602823

 Popiolek DA, Yee H, Mittal K, Chiriboga L, Prinz MK, Caragine TA, Budimlija ZM. Multiplex short tandem repeat DNA analysis confirms the accuracy of p57(KIP2) immunostaining in the diagnosis of complete hydatidiform mole. Hum Pathol. 2006 Nov;37(11):1426-34. PMID: 16949913

 Romaguera RL, Rodriguez MM, Bruce JH, Zuluaga T, Viciana A, Penalver MA, Mehrdad N. Molar gestations and hydropic abortions differentiated by p57 immunostaining. Fetal Pediatr Pathol. 2004 Mar-Jun;23(2-3):181-90. PMID: 15768863

 Jun SY, Ro JY, Kim KR. p57kip2 is useful in the classification and differential diagnosis of complete and partial hydatidiform moles. Histopathology. 2003 Jul;43(1):17-25. PMID: 12823708