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centriole

HP:8399

The centrosome consists of two centrioles, each comprising nine microtubule triplets that form a barrel-shaped structure that is approximately 0.5 m long and 0.2 m in diameter.

In eukaryotic cells, centrioles and their structural equivalents, basal bodies, play essential roles. They are needed for the assembly of flagella or cilia as well as for cell division. Genes for two new members of the tubulin superfamily are needed for basal body/centriole duplication.

Animal model

- Chlamydomonas reinhardtii provides an excellent model organism for the study of the basal body and centrioles.

See also

- centriolar proteins

References

- Badano JL, Teslovich TM, Katsanis N. The centrosome in human genetic disease. Nat Rev Genet. 2005 Mar;6(3):194-205. PMID: 15738963

- Dutcher SK. Elucidation of basal body and centriole functions in Chlamydomonas reinhardtii. Traffic. 2003 Jul;4(7):443-51. PMID: 12795689