TNFRSF11A
HGNC:11908 18q22.1 MIM.603499
Significant advances in bone biology have been made, including the discovery of RANK, RANK ligand (RANKL), and OPG as the key determinants of osteoclastogenesis.
Osteoclasts play an essential role in normal bone remodeling and are co-opted in cancer, functioning as part of the reactive bone microenvironment in metastatic dissemination and causing the skeletal morbidities experienced by patients with bone metastases or multiple myeloma.
See also
RANKL
osteoclasts
cancer-induced bone disease
RANKL inhibitors
denosumab
TNFRSFs
RANKL-RANK signaling
References
Wada T, Nakashima T, Hiroshi N, Penninger JM. RANKL-RANK signaling in osteoclastogenesis and bone disease. Trends Mol Med. 2005 Dec 12; PMID: #16356770#