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atypical lymphadenopathies

Friday 23 December 2005

Digital case

- HPC:333 : EBV-associated infectious mononucleosis (Lymph node)

Definition: Atypical lymphadenopathies fail to achieve the morphologic criteria of a malignant neoplasm, but exceed the usual concepts of follicular, lymphoid, or sinus histiocytic hyperplasias. Rich cellular proliferations usually composed of prominent histiocytes, or immunoblasts, or both with or without a vascular scaffolding obscure the nodal architecture.

Etiology

- infectious lymphadenitis

  • nodal toxoplasmosis
  • nodal infectious mononucleosis
  • nodal zoster
  • vaccination-induced lymphadenopathies

- dermatopathic lymphadenitis (associated with cutaneous disease)
- anticonvulsant pseudolymphoma

- Chediak-Higashi syndrome
- sinus histiocytosis with massive lymphadenopathy
- giant lymph node hyperplasia
- angioimmunoblastic lymphadenopathy
- nodal Kawasaki disease (mucocutaneous lymph node syndrome)

- nodal histiocytoses

  • acute disseminated histiocytosis

See also

- lymph nodes

  • adenitis
  • lymphadenopathies