FSCN1
Fascin-1 (FSCN1 or fascin) is an actin-bindling protein that plays an important role in cell motility and adhesion. Fascin-1 is expressed by dendritic cells in the blood and in tissues. The level of fascin-1 is low or undetectable in normal epithelial cells.
Expression in tumors
Fascin is expressed in many neoplasms including colorectal cancer. It is considered to be a mediator of tumor cell invasion and an indicator of aggressive phenotype; however, there are few reports on the association between fascin and prognosis in colorectal cancer.
juvenile xanthogranulomas (JXG) (#10463281#)
Rosai-Dorfman lesions (#10463281#)
soft tissue dendrocytomas (#10463281#)
Erdheim-Chester disease
classic Hodgkin lymphoma (100%) (#12579989#)
- Reed-Sternberg cells
anaplastic large cell lymphoma (ALCL) (67%) (cytoplasmic pattern) (#12579989#)
- T-cell ALCLs (59%) (#12579989#)
- null-cell ALCLs (77%) (#12579989#)
- ALK-1-positive ALCLs (91%) (#12579989#)
esophageal squamous cell carcinoma (ESCC) (#16524962#)
precancerous esophageal lesions (#16524962#)
colon cancer (colonic adenocarcinoma) (#20410808#)
- It is considered to be a mediator of tumor cell invasion and an indicator of aggressive phenotype.
- Fascin expression predicts survival after potentially curative resection of node-positive colon cancer. (#20410808#)
Pathology
Overexpression of FSCN1 is reported in transformed epithelial cells and in several common types of carcinomas.
An association is suggested between increased fascin-1 expression and increased invasiveness of carcinomas in the urinary bladder. (#16084942#)
See also
FSCNs
- FSCN2
References
Fascin Expression Predicts Survival After Potentially Curative Resection of Node-positive Colon Cancer. Chan C, Jankova L, Fung CL, Clarke C, Robertson G, Chapuis PH, Bokey L, Lin BP, Dent OF, Clarke S. Am J Surg Pathol. 2010 Apr 20. PMID: #20410808#
Zhang H, Xu L, Xiao D, Xie J, Zeng H, Cai W, Niu Y, Yang Z, Shen Z, Li E. Fascin is a potential biomarker for early-stage esophageal squamous cell carcinoma. J Clin Pathol. 2006 Mar 8; PMID: #16524962#
Fan G, Kotylo P, Neiman RS, Braziel RM. Comparison of fascin expression in anaplastic large cell lymphoma and Hodgkin disease. Am J Clin Pathol. 2003 Feb;119(2):199-204. PMID: #12579989#
Tong GX, Yee H, Chiriboga L, Hernandez O, Waisman J. Fascin-1 expression in papillary and invasive urothelial carcinomas of the urinary bladder. Hum Pathol. 2005 Jul;36(7):741-6. PMID: #16084942#
Jaffe R, DeVaughn D, Langhoff E. Fascin and the differential diagnosis of childhood histiocytic lesions. Pediatr Dev Pathol. 1998 May-Jun;1(3):216-21. PMID: #10463281#