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granulome faciale

Friday 18 November 2005

facial granulome

Digital case

- JRC:10502 : Granuloma faciale.



The pathogenesis of granuloma faciale (GF), framed in the group of cutaneous vasculopathic dermatitis, is poorly understood.

A significant number of GF cases are associated with an abnormal content of IgG4 plasma cells; this association was particularly obvious in male patients and in cases presenting with multiple or recurrent lesions.

As morphologic changes typically found in IgG4-RD, such as obliterative vascular inflammation and storiform sclerosis, are found in GF, it has been suggested that GF might represent a localized form of IgG4-RD. (23211291)

See also

-  cutaneous anomalies
- Vasculitis


- Granuloma Faciale: A Cutaneous Lesion Sharing Features With IgG4-associated Sclerosing Diseases. Cesinaro AM, Lonardi S, Facchetti F. Am J Surg Pathol. 2012 Dec 1. PMID: 23211291