granulome faciale

Digital case

 JRC:10502 : Granuloma faciale.

Images

 https://twitter.com/AngeloCassisa/status/594272506552397824

The pathogenesis of granuloma faciale (GF), framed in the group of cutaneous vasculopathic dermatitis, is poorly understood.

A significant number of GF cases are associated with an abnormal content of IgG4 plasma cells; this association was particularly obvious in male patients and in cases presenting with multiple or recurrent lesions.

As morphologic changes typically found in IgG4-RD, such as obliterative vascular inflammation and storiform sclerosis, are found in GF, it has been suggested that GF might represent a localized form of IgG4-RD. (23211291)

See also

  cutaneous anomalies
 Vasculitis

References

 Granuloma Faciale: A Cutaneous Lesion Sharing Features With IgG4-associated Sclerosing Diseases. Cesinaro AM, Lonardi S, Facchetti F. Am J Surg Pathol. 2012 Dec 1. PMID: 23211291