- Human pathology

Home > A. Molecular pathology > transcriptional silencing

transcriptional silencing

Saturday 19 July 2003

A crucial aspect of development, homeostasis and prevention of disease is the strict maintenance of patterns of gene repression.

Gene repression is largely achieved by the combinatorial action of various enzymatic complexes - known as co-repressor complexes - that are recruited to DNA by transcription factors and often act through enzymatic modification of histone protein tails.

See also

- co-repressors
- genome-scale data
- nuclear receptor co-repressor (NCoR, also known as NCOR1)
- silencing mediator of retinoic acid and thyroid hormone receptor (SMRT, also known as NCOR2) co-repressor complexes
- gene repression.


- Deconstructing repression: evolving models of co-repressor action. Perissi V, Jepsen K, Glass CK, Rosenfeld MG. Nat Rev Genet. 2010 Feb;11(2):109-23. PMID: 20084085

- Lande-Diner L, Cedar H. Silence of the genes—mechanisms of long-term repression. Nat Rev Genet. 2005 Aug;6(8):648-54. PMID: 16012529

- Shearwin KE, Callen BP, Egan JB. Transcriptional interference - a crash course. Trends Genet. 2005 Jun;21(6):339-45. PMID: 15922833