translocation-associated sarcomas
Exemples
alveolar rhabdomyosarcoma
- t(2;13)(q35;q14) (PAX3-FOXO1A)
- t(1;13)(p36;q14) (PAX7-FOXO1A)
myxoid liposarcoma
- t(12;16)(q13;p11) (FUS-DDIT3)
- t(12;22)(q13;q12) (EWSR1-DDIT3)
congenital fibrosarcoma and cellualr mesoblastic nephroma
- t(12;15)(p13;q26) (ETV6-NTRK3)
dermatofibrosarcoma protuberans/giant cell fibroblastoma:
- t(17;22)(q22;q13) (COL1A1-PDGFB)
alveolar soft part sarcoma
- t(X;17)(p11;q25) (TFE3-ASPL)
synovial sarcoma
- t(X;18)((p11.2;q11.2) (SS1B-SSX1; SS1B-SSX2; SS1B-SSX4)
Ewing sarcoma/Primitive neuroectodermal tumor
- t(11;22)(q24;q12) (EWS-FLI1)
- t(21;22)(q22;q12) (EWS-ERG) (ERG at 21q22)
- t(7;22)(p22;q12) (EWS-ETV1) (ETV1 at 7p22)
- t(17;22)(q12;q12) (EWS-E1AF) (E1AF at 17q12)
- t(2;22)((q33;q12) (EWS-FEV) (FEV at 2q23)
- t(22;22)(q1;q12) (EWS-ZSG)
epithelioid sarcoma
desmoplastic small round cell tumor
- t(11;22)(p13;q12) (EWS-WT1)
extraskeletal myxoid chrondrosarcoma
- t(9;22)(q22;q12) (EWS-NR4A3)
- t(9;17)(q22;q11) (RBP56-NR4A3)
- t(9;15)(q22;q21) (TCF12-NR4A3)
clear cell sarcoma of the soft tissue (soft part melanoma)
- t(12;22)(q13;q12) (EWS-ATF1)
angiomatoid fibrous histiocytoma
- t(12;16)(q13;p11) (FUS-ATF1)
endometrial stromal sarcoma
- t(7;17)(p15;q21) (JAZF1-JJAZ1)
low-grade fibromyxoid sarcoma
- t(7;16)(q33;p11) (FUS-CREB3L2)
- t(11;16)(p11;p11) (FUS-CREB3L1)
inflammatory myofibroblastic tumor
- t(1;2)(q22;q23) (TPM3-ALK)
- t(2;19)(p23;p13) (TPM4-ALK)
- t(2;17)(p23;p13) (CLTC-ALK)
- t(2;2)(p23;q13) (RANBP2-ALK)
See also
Sarcomas
- nontranslocation-associated sarcomas
References
Montgomery E, Argani P, Hicks JL, DeMarzo AM, Meeker AK. Telomere lengths of translocation-associated and nontranslocation-associated sarcomas differ dramatically. Am J Pathol. 2004 May;164(5):1523-9. PMID: #15111298#