metanephric renal tumors

Definition: The metanephric family of renal tumors encompasses metanephric adenofibroma , metanephric adenoma and metanephric stromal tumor ( in children).

Examples

 metanephric adenoma

• https://twitter.com/sam_albadri/status/782604426598985729
• https://twitter.com/RyanneMDMBA/status/819746736537120768
• https://twitter.com/WebPathology/status/851903465806864385
• http://www.webpathology.com/case.asp?case=65

Molecular pathology

 BRAF exon 15 mutations have been observed in 88% of metanephric adenomas, , in metanephric stromal tumors and in in metanephric adenofibroma.

 BRAF exon 15 mutation in metanephric stromal tumors

• found in 11/17 cases (65%) of metanephric stromal tumors, all corresponding to a thymidine to adenine substitution at codon 600 (BRAF V600E).
• All other renal stromal tumors tested were negative for BRAF exon 15 mutations. -* BRAF V600E mutations are encountered in the majority of metanephric stromal tumors, supporting a link with other metanephric tumors and suggesting a clonal event possibly affecting primordial renal cells.
• BRAF V600E mutations have been associated with oncogene-induced senescence in other benign tumors, providing clues to the pathogenesis of these neoplasms in keeping with their overall benign behavior.
• Results also suggest a potential diagnostic use for BRAF exon 15 mutations in differentiating metanephric stromal tumors from other pediatric renal stromal tumors, particularly in limited samples.