1p LOH

Tumors

 parathyroid tumors
 neuroblastomas
 Wilms tumor (17243164, 17370329)
 oligodendroglial tumors

• oligodendrogliomas
• glioblastomas

Subregions

 1p36 LOH

• neuroblastomas

  1p13 LOH (17370329)

• Wilms tumor (17243164)

 1p36-pter LOH

• germ cell tumors (16897744)

 1p22.3 LOH

• mantle cell lymphoma (16830336)

Candidate genes

 ENO1

See also

 Oncobase

References

 Detection of allelic status of 1p and 19q by microsatellite-based PCR versus FISH: limitations and advantages in application to patient management. Jha P, Sarkar C, Pathak P, Sharma MC, Kale SS, Gupta D, Chosdol K, Suri V. Diagn Mol Pathol. 2011 Mar;20(1):40-7. PMID: 21326038

 Tamimi Y, Ziebart K, Desaulniers N, Dietrich K, Grundy P. Identification of a minimal region of loss on the short arm of chromosome 1 in Wilms tumor. Genes Chromosomes Cancer. 2007 Apr;46(4):327-35. PMID: 17243164

 Zahn S, Sievers S, Alemazkour K, Orb S, Harms D, Schulz WA, Calaminus G, Gobel U, Schneider DT. Imbalances of chromosome arm 1p in pediatric and adult germ cell tumors are caused by true allelic loss: a combined comparative genomic hybridization and microsatellite analysis. Genes Chromosomes Cancer. 2006 Nov;45(11):995-1006. PMID: 16897744

 Grundy PE, Breslow NE, Li S, Perlman E, Beckwith JB, Ritchey ML, Shamberger RC, Haase GM, D’Angio GJ, Donaldson M, Coppes MJ, Malogolowkin M, Shearer P, Thomas PR, Macklis R, Tomlinson G, Huff V, Green DM; National Wilms Tumor Study Group. Loss of heterozygosity for chromosomes 1p and 16q is an adverse prognostic factor in favorable-histology Wilms tumor: a report from the National Wilms Tumor Study Group. J Clin Oncol. 2005 Oct 10;23(29):7312-21. PMID: 16129848