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TNFs
Tuesday 30 August 2005
Tumor necrosis factor family cytokines (TNFs) function as prominent mediators of immune regulation and the inflammatory response.
Most TNF family cytokines are expressed as type II transmembrane proteins, with homology confined to approximately 150 C-terminal residues. The TNF ligands interact with a parallel family of receptors (TNFSFs).
Members
| TNFA | LTA (TNFB) |
References
Locksley RM, Killeen N, Lenardo MJ: The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104:487, 2001.
