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minocycline-induced hepatitis

Thursday 16 June 2005

Long-term use of minocycline, a synthetic tetracycline for treatment of acne, can lead to hepatitis that can mimic lupus-related hepatitis, AIH or overlap syndrome.

Autoimmune disease can develop within days of starting the drug or may be delayed for many years.

High titres of antinuclear antibodies (ANAs) are common, but smooth muscle (SMA) and other autoantibodies often are negative. Autoimmune markers may be elevated in chronic hepatitis due to drugs (drug-induced autoimmune hepatitis).

Inflammatory activity can be minimal to mild, and eosinophils are typically inconspicuous.

Marked fibrosis and cirrhosis are rare, and patients often improve after drug withdrawal.

Microvesicular and macrovesicular steatosis in response to minocycline have been reported, but these followed high-dose intravenous therapy rather than oral administration.

See also

- Hepatitis

  • drug-induced hepatitis


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