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drug-induced cholestasis

Wednesday 15 June 2005

Drugs induce cholestasis either at the level of hepatocytes, hepatocellular cholestasis, or at the level of bile ducts (drug-induced cholangiopathy).

Drug-induced cholangiopathy is classified into acute and prolonged forms. Both forms start off acutely with jaundice, pruritis, and elevations of hepatic enzymes; canalicular enzymes showing higher elevations than transaminases.

Exemples

- amytriptylin
- amoxicillin
- amoxicillin-calvulanic acid
- azathioprin
- beta-blockers
- benzodiazepines
- carbamazepine
- chlorpromazine
- cyclopsorin-A
- clindamycin
- clofibrate
- dapsone
- erythromycins
- ethambutol
- fluconazole
- haloperidol
- H2-blockers
- imipramine
- NSAIDs
- sulfonamides
- sulindac
- tricyclic antidepressants
- trimethoprim-sulfamethoxazole
- thaibendazole
- ticlopidine
- tamoxifen
- zonisamide (drug-induced ductopenia)

See also

- drug-induced hepatic lesions

  • drug-induced hepatitis

- immune-mediated drug-induced hepatic disease

References

- Histological patterns in drug-induced liver disease. Ramachandran R, Kakar S. J Clin Pathol. 2009 Jun;62(6):481-92. PMID: 19474352