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ADPRTLs
Friday 27 May 2005
Activation of ADP-ribosyltransferases (ADPRTLs), such as ADPRTL2, is an early cellular response to DNA strand breaks.
These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability.
Members
| ADPRTL1 (PARP1) | ADPRTL2 (PARP2) | ADPRTL3 (PARP3) |
References
Huber A, Bai P, de Murcia JM, de Murcia G. PARP-1, PARP-2 and ATM in the DNA damage response: functional synergy in mouse development. DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1103-8. PMID: 15279798
