colorectal tumorigenesis

Chromosomal instability

The most common form of genomic instability observed in colorectal cancer is chromosomal instability (CIN), whose molecular bases remain to be determined.

Reviews

 de la Chapelle A. Genetic predisposition to colorectal cancer. Nat Rev Cancer. 2004 Oct;4(10):769-80. PMID: 15510158

 Reymond MA, Steinert R, Kahne T, Sagynaliev E, Allal AS, Lippert H. Expression and functional proteomics studies in colorectal cancer. Pathol Res Pract. 2004;200(2):119-27. PMID: 15237920

 Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C. The significance of unstable chromosomes in colorectal cancer. Nat Rev Cancer. 2003 Sep;3(9):695-701. PMID: 12951588

 Kerr D. Clinical development of gene therapy for colorectal cancer. Nat Rev Cancer. 2003 Aug;3(8):615-22. PMID: 12894249

 Lynch HT, de la Chapelle A. Hereditary colorectal cancer. N Engl J Med. 2003 Mar 6;348(10):919-32. PMID: 12621137

 Rhodes JM, Campbell BJ. Inflammation and colorectal cancer: IBD-associated and sporadic cancer compared. Trends Mol Med. 2002 Jan;8(1):10-6. PMID: 11796261

 Bustin SA, Jenkins PJ. The growth hormone-insulin-like growth factor-I axis and colorectal cancer. Trends Mol Med. 2001 Oct;7(10):447-54. PMID: 11597519

 Remvikos Y, Muleris M, Salmon RJ, Dutrillaux B. Colorectal carcinogenesis: from chromosomal evolution pathways to molecular pathogenesis. Cancer Genet Cytogenet. 1997 Jan;93(1):63-73. PMID: 9062582

References

 Integrating chromosomal aberrations and gene expression profiles to dissect rectal tumorigenesis. Lips EH, van Eijk R, de Graaf EJ, Oosting J, de Miranda NF, Karsten T, van de Velde CJ, Eilers PH, Tollenaar RA, van Wezel T, Morreau H. BMC Cancer. 2008 Oct 29;8:314. PMID: 18959792 [Free]

 Habermann JK, Paulsen U, Roblick UJ, Upender MB, McShane LM, Korn EL, Wangsa D, Kruger S, Duchrow M, Bruch HP, Auer G, Ried T. Stage-specific alterations of the genome, transcriptome, and proteome during colorectal carcinogenesis. Genes Chromosomes Cancer. 2007 Jan;46(1):10-26. PMID: 17044061