- Human pathology

Home > E. Pathology by systems > Skin > primary cutaneous large B-cell lymphoma

primary cutaneous large B-cell lymphoma

Wednesday 11 May 2005

In the World Health Organization (WHO) 2008 classification 2 main types of primary cutaneous large B-cell lymphomas (PCLBCLs) are distinguished: primary cutaneous follicle center lymphoma (PCFCL) and primary cutaneous large B-cell lymphoma, leg type (PCBCL-LT).

PCFCL has a 5-year overall survival rate of 95%, and PCBCL-LT of approximately 50%.

Expression profiling studies have shown higher RNA expression of the IgM heavy chain in PCBCL-LT compared with PCFCL.

Hence, staining for IgM on paraffin-embedded sections seems to be an additional tool for differentiating between the 2 entities in clinical pathology practice.

Analogous to other nodal and extranodal large B-cell lymphomas, expression of IgM in PCLBCL seems to be related to an activated B cell-like phenotype. (20551823)

Finally, the expression of IgM (and IgD) in this type of lymphoma might imply defective class switch recombination. (20551823)


- IgM expression on paraffin sections distinguishes primary cutaneous large B-cell lymphoma, leg type from primary cutaneous follicle center lymphoma. Koens L, Vermeer MH, Willemze R, Jansen PM. Am J Surg Pathol. 2010 Jul;34(7):1043-8. PMID: 20551823

- Genetic Aberrations in Primary Cutaneous Large B-Cell Lymphoma: A Fluorescence In Situ Hybridization Study of 25 Cases. Wiesner T, Streubel B, Huber D, Kerl H, Chott A, Cerroni L. Am J Surg Pathol. 2005 May;29(5):666-673. PMID: 15832092