TNFRSF1A

Etiology

 TRAPS (TRAP syndrome) or autosomal dominant periodic fever (MIM.142680) is caused by mutations in the tumor necrosis factor receptor-1 gene (TNFRSF1A) (MIM.191190)

See also

 periodic fevers
 hereditary autoinflammatory diseases (HAID)

References

 A novel Y331X nonsense mutation in TNFRSF1A gene in two unrelated Turkish families with periodic fever syndrome. Kutukculer N, Gulez N, Karaca N, Aksu G, Berdeli A. Int J Immunogenet. 2009 Oct 5. PMID: 19804406

 TNF receptor-associated periodic syndrome (TRAPS): A new cause of joint destruction? Schoindre Y, Feydy A, Giraudet-Lequintrec JS, Kahan A, Allanore Y. Joint Bone Spine. 2009 Sep 29. PMID: 19796978

 Multiple sclerosis. TNFRSF1A, TRAPS and multiple sclerosis. Kümpfel T, Hohlfeld R. Nat Rev Neurol. 2009 Oct;5(10):528-9. PMID: 19794511

 McDermott MF. Genetic clues to understanding periodic fevers, and possible therapies. Trends Mol Med. 2002 Dec;8(12):550-4. PMID: 12470987

 Drenth JP, van der Meer JW. Hereditary periodic fever. N Engl J Med. 2001 Dec 13;345(24):1748-57. PMID: 11742050

 Centola M, Aksentijevich I, Kastner DL. The hereditary periodic fever syndromes: molecular analysis of a new family of inflammatory diseases. Hum Mol Genet. 1998;7(10):1581-8. PMID: 9735379