RANBP2

Pathology

 Fusion of ALK to the Ran-binding protein 2 (RANBP2) gene in :

• ALK-associated inflammatory myofibroblastic tumor (12661011) at 2q11-q13 by t(2;2)(p23;q13)
• ALK-associated epithelioid inflammatory myofibroblastic sarcoma ( RANBP2-ALK )

Open references

 A case report of epithelioid inflammatory myofibroblastic sarcoma with RANBP2-ALK fusion gene treated with the ALK inhibitor, crizotinib.
Kimbara S, Takeda K, Fukushima H, Inoue T, Okada H, Shibata Y, Katsushima U, Tsuya A, Tokunaga S, Daga H, Okuno T, Inoue T.
Jpn J Clin Oncol. 2014 Sep;44(9):868-71. doi : 10.1093/jjco/hyu069
PMID: 25028698 Free

Paywall References

 Ma Z, Hill DA, Collins MH, Morris SW, Sumegi J, Zhou M, Zuppan C, Bridge JA. Fusion of ALK to the Ran-binding protein 2 (RANBP2) gene in inflammatory myofibroblastic tumor. Genes Chromosomes Cancer. 2003 May;37(1):98-105. PMID: 12661011