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hematopoietic stem cells
Sunday 13 July 2003
Haematopoietic stem cells (HSCs) are multipotent, self-renewing progenitors that generate all mature blood cells.
HSC function is tightly controlled to maintain haematopoietic homeostasis, and this regulation relies on specialized cells and factors that constitute the haematopoietic ’niche’, or microenvironment.
References
Dynamic niches in the origination and differentiation of haematopoietic stem cells. Wang LD, Wagers AJ. Nat Rev Mol Cell Biol. 2011 Sep 2;12(10):643-55. PMID: 21886187
Chute JP. Stem cell homing. Curr Opin Hematol. 2006 Nov;13(6):399-406. PMID: 17053451
Orkin SH. Diversification of haematopoietic stem cells to specific lineages. Nat Rev Genet. 2000 Oct;1(1):57-64. PMID: 11262875
