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acquired renal cystic disease

Friday 4 March 2005

Acquired renal cystic disease (ARCD) complicating end-stage renal failure confers an increased risk for renal cell carcinoma, and atypical epithelial proliferation in the cysts may represent the precursor lesion.

Synopsis

- renal simple cysts
- renal atypical cysts

  • papillary tufts
  • cribriform epithelial proliferation

Cytogenetics

- gain of chromosome 7 in the papillary tufts (12196929)
- gain of chromosomes 7 and 17 in cribriform lesions (12196929)
- gain of chromosomes 7, 12, 17, 20, and Y in the atypical cysts (12196929)

Etiology

Complications

- renal cell carcinoma

References

- Cheuk W, Lo ES, Chan AK, Chan JK. Atypical epithelial proliferations in acquired renal cystic disease harbor cytogenetic aberrations. Hum Pathol. 2002 Jul;33(7):761-5. PMID: 12196929

- Ikeda R, Tanaka T, Moriyama MT, Kawamura K, Miyazawa K, Suzuki K. Proliferative activity of renal cell carcinoma associated with acquired cystic disease of the kidney: comparison with typical renal cell carcinoma. Hum Pathol. 2002 Feb;33(2):230-5. PMID: 11957150