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acquired renal cystic disease
Friday 4 March 2005
Acquired renal cystic disease (ARCD) complicating end-stage renal failure confers an increased risk for renal cell carcinoma, and atypical epithelial proliferation in the cysts may represent the precursor lesion.
Synopsis
renal simple cysts
renal atypical cysts
- papillary tufts
- cribriform epithelial proliferation
Cytogenetics
gain of chromosome 7 in the papillary tufts (12196929)
gain of chromosomes 7 and 17 in cribriform lesions (12196929)
gain of chromosomes 7, 12, 17, 20, and Y in the atypical cysts (12196929)
Etiology
Complications
renal cell carcinoma
References
Cheuk W, Lo ES, Chan AK, Chan JK. Atypical epithelial proliferations in acquired renal cystic disease harbor cytogenetic aberrations. Hum Pathol. 2002 Jul;33(7):761-5. PMID: 12196929
Ikeda R, Tanaka T, Moriyama MT, Kawamura K, Miyazawa K, Suzuki K. Proliferative activity of renal cell carcinoma associated with acquired cystic disease of the kidney: comparison with typical renal cell carcinoma. Hum Pathol. 2002 Feb;33(2):230-5. PMID: 11957150