Home > G. Tumoral pathology > mesenchymal chondrosarcoma
mesenchymal chondrosarcoma
Friday 4 March 2005
Images
mesenchymal chondrosarcoma NGS: cartilage islands w/ background of undifferentiated small round cells; HPC-like vessels.
- https://twitter.com/histiocytosisX/status/798903947461361664
- https://twitter.com/ARP_Press/status/811371852107051008
Synopsis
mixture of undifferentiated small cells and mature hyaline cartilage islands, positive for vimentin, S-100 and CD99.
Molecular biology
HEY1 and NCOA2 fusion gene : HEY1-NCOA2
Localization
skeletal mesenchymal chondrosarcoma
extra-skeletal mesenchymal chondrosarcoma
Variants
intracranial mesenchymal chondrosarcoma (17990930)
neonatal mesenchymal chondrosarcoma (17990930)
Cytogenetics
trisomy 8 (15899388)
translocation der(13;21)(q10;q10) (12011263)
t(4;9)(q23;q22) (8603349)
t(1;20)(q21;q13) (8603349)
t(11;22)(q24;q12) (8281518)
add(7)(p13) (7656206)
add(22)(q13) (7656206)
References
Gatter KM, Olson S, Lawce H, Rader AE. Trisomy 8 as the sole cytogenetic abnormality in a case of extraskeletal mesenchymal chondrosarcoma. Cancer Genet Cytogenet. 2005 Jun;159(2):151-4. PMID: 15899388
Muller S, Soder S, Oliveira AM, Inwards CY, Aigner T. Type II collagen as specific marker for mesenchymal chondrosarcomas compared to other small cell sarcomas of the skeleton. Mod Pathol. 2005 Feb 25 PMID: 15731776
Szymanska J, Tarkkanen M, Wiklund T, Virolainen M, Blomqvist C, Asko-Seljavaara S, Tukiainen E, Elomaa I, Knuutila S. Cytogenetic study of extraskeletal mesenchymal chondrosarcoma. A case report. Cancer Genet Cytogenet. 1996 Feb;86(2):170-3. PMID: 8603349
Sainati L, Scapinello A, Montaldi A, Bolcato S, Ninfo V, Carli M, Basso G. A mesenchymal chondrosarcoma of a child with the reciprocal translocation (11;22)(q24;q12). Cancer Genet Cytogenet. 1993 Dec;71(2):144-7. PMID: 8281518