epithelioid hemangioma

Definition: Epithelioid hemangioma is an uncommon vascular tumefaction of uncertain pathogenesis.

Digital cases

 Case 162 (HPC:162) : Epithelioid hemangioma of bones (Hand)

 HALE / epithelioid hemangioma

• https://twitter.com/TheKarenPinto/status/954328802859024384
• https://twitter.com/ScottBikeethan/status/1454438452137693189

Images

 Epithelioid hemangioma

• https://twitter.com/KyleBradleyMD/status/743797449081368576

The anatomic sites most frequently affected by epithelioid hemangioma are the head (in the distribution of the superficial temporal artery) and the distal portions of the extremities, especially the digits.

Localization

 soft tissue epithelioid hemangioma
 penile epithelioid hemangioma (15087672)
 epithelioid hemangioma of bones

Microscopy

 proliferation of epithelioid endothelial cells
 nodular or lobular configuration
 inflammatory infiltrate containing lymphocytes and eosinophils
 associated with a small arterial segment

• mural damage
• intraluminal epithelioid endothelial cells

Molecular biology

 Frequent FOS Gene Rearrangements in epithelioid hemangioma (26135557)

See also

  vascular tumors

• epithelioid vascular tumors

 epithelioid cells

References

 Epithelioid hemangioma of bone revisited: a study of 50 cases. Nielsen GP, Srivastava A, Kattapuram S, Deshpande V, O’Connell JX, Mangham CD, Rosenberg AE. Am J Surg Pathol. 2009 Feb;33(2):270-7. PMID: 18852673