endocervical adenocarcinoma

Types (exemples)
 endocervical adenocarcinoma in situ
 invasive endocervical adenocarcinoma

Images

 63yo with atypical glandular cells on pap smear, endocervical adenocarcinoma

• https://twitter.com/solcosao/status/734812864469291011

Variants

 cervical villoglandular adenocarcinoma
 cervical minimal deviation adenocarcinoma (20416098 Free)

Differential diagnosis

 microglandular hyperplasia

• The microglandular hyperplasia shows non neoplastic back-to-back glands with a neutrophilic infiltrate, accompanied by squamous metaplasia.

 invasive endometrial carcinoma

• Invasive endometrial carcinoma shows malignant infiltrative glands with a desmoplastic response.
• It is differentiated from endocervical adenocarcinoma on IHC by positivity for vimentin and more frequent positivity for ER and PR.

See also

 uterine cervical tumors

• uterine cervical carcinomas

Open References

 Clonal status and clinicopathological observation of cervical minimal deviation adenocarcinoma. Gong L, Zhang WD, Liu XY, Han XJ, Yao L, Zhu SJ, Lan M, Li YH, Zhang W. Diagn Pathol. 2010 Apr 24;5(1):25. PMID: 20416098 (Free Article)

References

 Invasive Endocervical Adenocarcinoma: A New Pattern-based Classification System With Important Clinical Significance. Roma AA, Diaz De Vivar A, Park KJ, Alvarado-Cabrero I, Rasty G, Chanona-Vilchis JG, Mikami Y, Hong SR, Teramoto N, Ali-Fehmi R, Rutgers JK, Barbuto D, Silva EG. Am J Surg Pathol. 2015 Feb 25. PMID: 25724003

 Endocervical Adenocarcinomas With Prominent Endometrial or Endomyometrial Involvement Simulating Primary Endometrial Carcinomas: Utility of HPV DNA Detection and Immunohistochemical Expression of p16 and Hormone Receptors to Confirm the Cervical Origin of the Corpus Tumor. Yemelyanova A, Vang R, Seidman JD, Gravitt PE, Ronnett BM. Am J Surg Pathol. 2009 Mar 17. PMID: 19295407