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CMV-associated gastritis

Monday 7 February 2005

CMV gastritis; Cytomegalovirus gastritis



- CMV gastritis

The only viral infections of the stomach with a distinct pathologic appearance are those caused by cytomegalovirus (CMV).

CMV gastritis is seen almost exclusively in children and immunocompromised patients. Usually it is associated with concurrent CMV infection of other sites of the digestive tract.

Endoscopically, the gastric mucosa may appear completely normal or show erosions or shallow ulcers.

Rarely, it may present as a grossly nodular mucosa that has been referred to as a pseudotumor.

In children, a hypertrophic gastritis similar to Menetrier disease may develop.

The histopathologic appearance varies depending on the patient’s ability to mount an immune response.

In some patients, particularly those with very low CD4 counts, numerous CMV inclusions may be seen in epithelial and endothelial cells as well as in macrophages, with little or no inflammatory response in the adjacent tissues.

In other patients, one may see a florid mixed inflammatory reaction with abundant granulation tissue, and typical CMV inclusions may be difficult to detect without using immunohistochemistry or in situ hybridization techniques.

Intense eosinophil infiltration in the lamina propria accompanied by peripheral eosinophilia has been noted, suggesting an allergic component to the gastritis in some patients.


- CMV hypertrophic gastritis
- CMV hemorrhagic gastritis


§ Generally associated with bone marrow transplants, AIDS, other immunosuppression
§ In pediatric population may be associated with hypertrophic gastropathy
§ Gastric involvement usually part of systemic disease
§ May cause gastric perforation or gastric fistula
§ Eosinophilic intranuclear inclusions,
§ variable granular purple cytoplasmic inclusions
§ Severe cases have ulceration, hemorrhage and perforation

See also

- hypertrophic gastropathy
- gastritis