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paraganglioma-like dermal melanocytic tumor
Friday 14 January 2005
PDMT
Definition : PDMT is primarily a tumor of the extremities of adult females which present as a dermal nodule composed of nests of clear to amphophilic oval cells separated by delicate fibrous strands.
Synopsis
dermal nodule
nests of clear to amphophilic oval cells separated by delicate fibrous strands
mild nuclear atypia
low mitotic activity
melanin not obvious
Immunochemistry
S-100+
Melan-A+
HMB-45+
microphthalmia transcription factor +
CK- (pancytokeratin -)
SMA- (smooth muscle actin -)
Differential diagnosis
cellular blue nevus
clear cell sarcoma
cutaneous melanoma
Open references
Paraganglioma-like dermal melanocytic tumor. Thyvalappil A, Sudhamani B, Kizhakkethara G, Sridharan R, Kunjan R. Indian J Dermatol. 2015 Jan-Feb;60(1):80-1. doi : 10.4103/0019-5154.147804 PMID: 25657403
References
Deyrup AT, Althof P, Zhou M, Morgan M, Solomon AR, Bridge JA, Weiss SW. Paraganglioma-like dermal melanocytic tumor: a unique entity distinct from cellular blue nevus, clear cell sarcoma, and cutaneous melanoma. Am J Surg Pathol. 2004 Dec;28(12):1579-86. PMID: 15577676
