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multifocal myocardial necrosis

Sunday 9 January 2005

Multifocal myocardial necrosis (MMN) is an unusual cardiomyopathy of childhood, characterized by multiple patchy areas of myocardial fiber necrosis/fibrosis involving mainly the middle part of the left ventricle, but also, to a lesser extent, the right ventricle and the atria. These necrotic lesions are isolated and are not accompanied by an inflammatory reaction or vascular alterations. They are responsible for acute cardiac failure.

Etiology

- cystic fibrosis of the pancreas
- pancreatic lipomatous hypoplasia/atrophy
- malnutrition due to extensive intestinal resection with subsequent total parenteral feeding
- Keshan disease

References

- Beranek JT. Letter to the editor—multifocal myocardial apoptoses: distinctive cardiac lesions in cystic fibrosis and other diseases. Pediatr Pathol Mol Med. 2003 Mar-Apr;22(2):187-8. PMID: 12556300

- Nezelof C, Bouvier R, Dijoud F. Multifocal myocardial necrosis: a distinctive cardiac lesion in cystic fibrosis, lipomatous pancreatic atrophy, and Keshan disease. Pediatr Pathol Mol Med. 2002 May-Jun;21(3):343-52. PMID: 12056507