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Loffler endocarditis

Thursday 6 January 2005

Loffler endocarditis is characterized by an eosinophilic endomyocardial fibrosis. Loffler endocarditis refers to the cardiac component of the hypereosinophilic syndromes, which determines patient morbidity and mortality.

Pathological synopsis

- mature eosinophils infiltrate
- damage to the endocardium and myocardium

Clinical synopsis

- weight loss
- fever
- cough
- rash
- congestive heart failure

Etiology

- hypereosinophilic syndrome (HES)
- eosinophilic leukemia
- carcinomas
- lymphomas
- drug reactions
- parasitic infections

Associations

- pulmonary infiltrates
- peripheral eosinophilia