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intra-uterine growth retardation

Tuesday 14 December 2004

Intrauterine growth retardation (IUGR) is caused by maternal, fetal or placental factors that result in impaired endovascular trophoblast invasion and reduced placental perfusion. Although various causes of intrauterine growth retardation have been identified, most cases remain unexplained.


- harmonious IUGR (symetrical IUGR)
- dysharmonious IUGR (assymetrical IUGR)

  • relative macrocephaly

Etiology (exemples)

- placental insufficiency
- maternal smoking
- IGF1 resistance
- 3-M syndrome (MIM.273750) (CUL7 mutations)


- Vogt Isaksen C. Maternal smoking, intrauterine growth restriction, and placental apoptosis. Pediatr Dev Pathol. 2004 Sep-Oct;7(5):433-42. PMID: 15568214